Fig. 3
From: Spirometric changes during exacerbations of COPD: a post hoc analysis of the WISDOM trial
a Change from Week − 8 in on-treatment weekly FEV1 before and after first moderate/severe exacerbation. b Change from Week − 8 in on-treatment weekly FEV1 before and after first moderate exacerbation. c Change from Week − 8 in on-treatment weekly FEV1 before and after first severe exacerbation. All graphs show both treatments combined. Plots include patients whose first exacerbation after the ICS withdrawal visit was neither preceded by an exacerbation of any severity in 8 weeks prior nor followed by a further exacerbation of any severity within 8 weeks (56 days) after exacerbation. Patients had weekly means available for the entire period of interest. FEV1, forced expiratory volume in 1 s; ICS, inhaled corticosteroids; SE, standard error