Skip to main content

Table 2 Serum concentration of inflammatory mediators associated with T2DM in women with and without COPD by TS, BS and healthy control women. n = 70

From: Women with COPD by biomass show different serum profile of adipokines, incretins, and peptide hormones than smokers

Inflammatory mediator Control COPD-TS COPD-BS
C-peptide 0.103 (0.072–0.190) 0.614 (0.333–0.864)* 0.400 (0.251–0.730)*
Ghrelin 0.026 (0.016–0.560) 0.066 (0.035–0.123)* 0.296 (0.082–0.397)*/*
GIP 0.053 (0.038–0.097) 0.092 (0.046–0.164)*** 0.073 (0.060–0.090)
GLP-1 0.026 (0.020–0.036) 0.062 (0.044–0.086)* 0.070 (0.060–0.090)*
Glucagon 0.189 (0.076–0.256) 0.100 (0.055–0.139)* 0.110 (0.090–0.133)*
Insulin 0.163 (0.077–0.294) 0.226 (0.140–0.452) 0.485 (0.208–0.743)*/**
Leptin 0.706 (0.264–1.131) 1.737 (0.524–3.239)** 2.96 (1.033–6.720)*/***
PAI-1 15.080 (10.01–19.71) 9.628 (4.626–17.57)*** 23.24 (13.64–28.56)*/*
Resistin 0.352 (0.140–0.506) 0.103 (0.207–0.680)*** 0.065 (0.097–0.748)*
Visfatin 0.617 (0.508–1.012) 0.253 (0.127–0.423)* 0.817 (0.360–1.490) /*
  1. All measures are expressed in ng/ml. Serum concentration of biomarkers are presented as median (interquartile ranges). * P < 0.0001. ** P < 0.01. *** P < 0.05. * vs control; /* COPD-BS vs COPD-TS
  2. Abbreviations: BS biomass smoke exposure, GIP gastric inhibitory polypeptide, GLP-1 glucagon-like peptide-1, PAI-1 plasminogen activator inhibitor-1, TS tobacco smoking, T2DM type 2 Diabetes mellitus