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Table 2 Serum concentration of inflammatory mediators associated with T2DM in women with and without COPD by TS, BS and healthy control women. n = 70

From: Women with COPD by biomass show different serum profile of adipokines, incretins, and peptide hormones than smokers

Inflammatory mediator

Control

COPD-TS

COPD-BS

C-peptide

0.103 (0.072–0.190)

0.614 (0.333–0.864)*

0.400 (0.251–0.730)*

Ghrelin

0.026 (0.016–0.560)

0.066 (0.035–0.123)*

0.296 (0.082–0.397)*/*

GIP

0.053 (0.038–0.097)

0.092 (0.046–0.164)***

0.073 (0.060–0.090)

GLP-1

0.026 (0.020–0.036)

0.062 (0.044–0.086)*

0.070 (0.060–0.090)*

Glucagon

0.189 (0.076–0.256)

0.100 (0.055–0.139)*

0.110 (0.090–0.133)*

Insulin

0.163 (0.077–0.294)

0.226 (0.140–0.452)

0.485 (0.208–0.743)*/**

Leptin

0.706 (0.264–1.131)

1.737 (0.524–3.239)**

2.96 (1.033–6.720)*/***

PAI-1

15.080 (10.01–19.71)

9.628 (4.626–17.57)***

23.24 (13.64–28.56)*/*

Resistin

0.352 (0.140–0.506)

0.103 (0.207–0.680)***

0.065 (0.097–0.748)*

Visfatin

0.617 (0.508–1.012)

0.253 (0.127–0.423)*

0.817 (0.360–1.490) /*

  1. All measures are expressed in ng/ml. Serum concentration of biomarkers are presented as median (interquartile ranges). * P < 0.0001. ** P < 0.01. *** P < 0.05. * vs control; /* COPD-BS vs COPD-TS
  2. Abbreviations: BS biomass smoke exposure, GIP gastric inhibitory polypeptide, GLP-1 glucagon-like peptide-1, PAI-1 plasminogen activator inhibitor-1, TS tobacco smoking, T2DM type 2 Diabetes mellitus
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Respiratory Research

ISSN: 1465-993X

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