Women with COPD by biomass show different serum profile of adipokines, incretins, and peptide hormones than smokers

Table 1 Demographics, physiological and clinical characteristics in women with and without COPD associated with TS and BS, and control healthy women. n = 70

	C	COPD-TS	COPD-BS
Characteristics
Age (years)	67.26 ± 7.32	6.62 ± 7.79^**	73.77 ± 7.46^/^
Height (cm)	147 ± 5.6	155.14 ± 7.92^/^	146.24 ± 5.28/^**
Weight (kg)	58 ± 11	63.49 ± 13.52^*	57.78 ± 11.68
BMI (kg/m²)	26 ± 6	26.52 ± 6.13	27.5 ± 5.28
Exposure and physiological characteristics
Tobacco index (pack-years)	0	37.28 ± 11.43	0
Biomass index (h-years of exposure)	0	0	361 ± 177
Exposure to biomass smoke (h-days)	0	0	7.17 ± 2.56
FEV₁% pred	96.91 ± 13.36	52.40 ± 19.92^***	58.40 ± 14.80*
FVC% pred	109.8 ± 9.1	79.49 ± 20.86*	83.10 ± 16.62*
FEV₁/FVC ratio	92 ± 9.6	53.38 ± 12.62***	56.87 ± 12.11*
BODE	0	3.45 ± 2.86	2.91 ± 1.94
6MWT (m)	0	286.47 ± 174.23	318.91 ± 102.99
Clinical parameters
PaO₂ (mm/Hg)	0	55.18 ± 14.65	55.1 ± 1.94
PaCO₂ (mm/Hg)	0	40.88 ± 11.83	33.95 ± 5.62
SaO₂ (%)	0	89.54 ± 4.19	89.16 ± 4.03
Glucose	95.0 ± 10.0	101.86 ± 24.5	109.94 ± 28.49**
C-reactive protein	0.28 ± 0.32	0.56 ± 0.62**	0.50 ± 0.51**
GOLD grades Case number (%)
I	0	5 (8.57)	7 (10)
II	0	27 (38.57)	41 (58.57)
III	0	23 (32.86)	16 (22.86)
IV	0	15 (21.43)	6 (8.57)

Data are expressed as mean ± SD. Definition of abbreviations: BMI, body mass index; FEV₁% pred, forced expiratory volume in the 1st sec (% predicted); FVC% pred, forced vital capacity (% predicted). Data were analyzed by one-way ANOVA and Tukey’s post hoc test. * P < 0.0001. ** P < 0.01. *** P < 0.05. * vs Control; /* COPD-BS vs COPD-TS
Abbreviations: BMI body mass index, COPD-BS COPD by biomass smoke exposure, COPD-TS COPD secondary to tobacco smoking, FEV₁% pred forced expiratory volume in the 1st sec (% predicted), FVC% pred forced vital capacity (% predicted)

ISSN: 1465-993X