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Table 3 Risk factors associated with transplant-free 30-day and 90-day mortality in cirrhotic patients with pneumonia

From: Pneumonia in patients with cirrhosis: risk factors associated with mortality and predictive value of prognostic models

Variables 90-day 30-day
Univariate   Multivariate   Univariate   Multivariate  
HR (95% CI) P value HR (95% CI) P value HR (95% CI) P value HR (95% CI) P value
  Model 1: Baseline parameters     Model 1: Baseline parameters    
Age 1.000 (0.982–1.018) 0.998 1.020 (1.001–1.041) 0.043 1.004 (0.981–1.027) 0.761   
Multilobar infiltration 2.474 (1.125–5.443) 0.024    1.954 (0.760–5.027) 0.164   
Bacteremia 2.88 (1.419–5.843) 0.003 2.651 (1.488–4.724) 0.001 2.293 (0.894–5.877) 0.084 3.037 (1.515–6.090) 0.002
Inappropriate empirical antibiotic use 8.894 (4.516–17.516) <0.001 3.126 (1.726–5.662) <0.001 7.645 (3.194–18.295) <0.001 2.326 (1.158–4.673) 0.018
SIRS 3.061 (1.662–5.637) <0.001    2.788 (1.278–6.084) 0.01   
Ascites 2.931 (1.264–6.800) 0.012    1.918 (0.749–4.912) 0.175   
Hepatorenal syndrome 3.847 (2.238–6.614) <0.001    3.013 (1.494–6.076) 0.002   
Hepatic encephalopathy 3.534 (2.073–6.023) <0.001    3.416 (1.746–6.683) <0.001   
  Model 2: Laboratory exam     Model 2: Laboratory exam    
Age 1.000 (0.982–1.018) 0.998 1.026 (1.006–1.047) 0.013 1.004 (0.981–1.027) 0.761 1.024 (0.997–1.051) 0.082
WBC (109 /L) 1.070 (1.048–1.091) <0.001 1.551 (1.358–1.771) <0.001 1.066 (1.040–1.092) <0.001 1.452 (1.257–1.676) <0.001
Platelet count (109/L) 0.986 (0.979–0.994) <0.001    0.989 (0.980–0.998) 0.012   
INR 1.273 (1.190–1.362) <0.001    1.242 (1.163–1.326) <0.001   
Total Bilirubin (mg/dL) 1.003 (1.001–1.004) <0.001 1.059 (1.021–1.098) 0.002 1.003 (1.001–1.004) 0.004   
Hemoglobin (g/L) 0.985 (0.975–0.996) 0.006    0.991 (0.978–1.004) 0.159   
HCT 0.938 (0.903–0.976) 0.001    0.955 (0.912–1.000) 0.052   
Creatinine (μmol/L) 1.003 (1.001–1.004) <0.001    1.003 (1.001–1.004) 0.004   
Glucose 1.075 (1.046–1.105) <0.001    1.060 (1.019–1.102) 0.004   
  Model 3:
Severity scores
    Model 3:
Severity scores
   
CLIF-SOFA score 1.319 (1.250–1.393) <0.001    1.296 (1.213–1.386) <0.001   
Child-Pugh C grade 7.024 (3.193–15.450) <0.001    5.198 (2.025–13.344) 0.001   
MELD 1.096 (1.076–1.117) <0.001    1.086 (1.061–1.112) <0.001   
MELD-Na 1.066 (1.050–1.083) <0.001    1.062 (1.041–1.083) <0.001   
PSI scores 1.023 (1.018–1.028) <0.001    1.024 (1.017–1.031) <0.001   
qSOFA≥2 6.248 (3.752–10.402) <0.001    8.654 (4.546–16.474) <0.001