Table 2 Gene ontologies: Molecular functions of differentially expressed genes
ID | Name | p-value | q-value, Bonferroni | q-value, FDR B&H | q-value, FDR B&Y | Hit Count in Query List | Hit Count in Genome | Hit in Query List |
|---|---|---|---|---|---|---|---|---|
GO:0038187 | pattern recognition receptor activity | 5.52E− 07 | 3.76E− 04 | 1.88E− 04 | 1.34E− 03 | 5 | 17 | CLEC7A, LY96, PTAFR, CD14, TLR2 |
GO:0008329 | signaling pattern recognition receptor activity | 5.52E−07 | 3.76E−04 | 1.88E− 04 | 1.34E−03 | 5 | 17 | CLEC7A, LY96, PTAFR, CD14, TLR2 |
GO:0001875 | lipopolysaccharide receptor activity | 9.92E−06 | 6.75E−03 | 2.25E− 03 | 1.60E− 02 | 3 | 5 | LY96, PTAFR, TLR2 |
GO:0042497 | triacyl lipopeptide binding | 1.02E−04 | 6.95E− 02 | 1.39E− 02 | 9.87E− 02 | 2 | 2 | TLR1, TLR2 |
GO:0016230 | sphingomyelin phosphodiesterase activator activity | 1.02E−04 | 6.95E−02 | 1.39E− 02 | 9.87E− 02 | 2 | 2 | STX4, NSMAF |
GO:0042277 | peptide binding | 1.24E−04 | 8.44E−02 | 1.41E− 02 | 9.99E− 02 | 11 | 278 | HLA-B, HLA-E, FFAR4, NFKBIA, TAP1, NUP98, PPIF, FURIN, TLR1, TLR2, SLC7A5 |
GO:0016004 | phospholipase activator activity | 2.07E−04 | 1.41E−01 | 1.92E−02 | 1.36E−01 | 3 | 12 | STX4, CCL3, NSMAF |
GO:0042287 | MHC protein binding | 2.54E−04 | 1.73E−01 | 1.92E−02 | 1.36E−01 | 4 | 31 | LILRB2, HLA-E, CLEC7A, TAP1 |
GO:0042605 | peptide antigen binding | 2.88E−04 | 1.96E−01 | 1.92E−02 | 1.36E−01 | 4 | 32 | HLA-B, HLA-E, TAP1, SLC7A5 |
GO:0033218 | amide binding | 3.09E−04 | 2.11E−01 | 1.92E−02 | 1.36E−01 | 11 | 309 | HLA-B, HLA-E, FFAR4, NFKBIA, TAP1, NUP98, PPIF, FURIN, TLR1, TLR2, SLC7A5 |
GO:0005102 | receptor binding | 3.11E−04 | 2.12E−01 | 1.92E−02 | 1.36E−01 | 31 | 1601 | RELN, HLA-B, LILRB2, HLA-E, ETS2, CLEC7A, LRG1, ADM, CMTM6, TYROBP, TMC8, CCL3, CCL4, FGR, TAP1, PLSCR1, NSMAF, SECTM1, PROK2, SELPLG, ICAM1, CCL3L3, SH2B2, NAMPT, GNA13, TNFSF13B, TLR1, TLR2, IRS2, LYN, IL1RN |
GO:0060229 | lipase activator activity | 3.38E−04 | 2.30E−01 | 1.92E−02 | 1.36E−01 | 3 | 14 | STX4, CCL3, NSMAF |
GO:0019899 | enzyme binding | 4.15E−04 | 2.83E−01 | 2.17E−02 | 1.54E−01 | 35 | 1929 | LILRB2, RNF19B, TNFRSF14, GBP1, PTAFR, CKB, SERPINB9, STX4, FGD4, CXCR4, XPO6, PLIN5, NFKBIA, EHD1, FGR, PLEK, NOS1, PLSCR1, ALOX5AP, SELL, RICTOR, LCP1, SH2B2, ZFP36, RHOH, LMNB1, FURIN, PPP1R18, IRS2, TNFAIP3, TNFRSF1B, LYN, TRIB1, MARCKS, SOD2 |
GO:0023029 | MHC class Ib protein binding | 5.98E−04 | 4.07E−01 | 2.91E−02 | 2.07E−01 | 2 | 4 | LILRB2, TAP1 |
GO:0070891 | lipoteichoic acid binding | 9.90E−04 | 6.74E−01 | 4.49E−02 | 3.19E−01 | 2 | 5 | CD14, TLR2 |
GO:0042288 | MHC class I protein binding | 1.17E−03 | 7.97E−01 | 4.74E−02 | 3.37E−01 | 3 | 21 | LILRB2, HLA-E, TAP1 |
GO:0042802 | identical protein binding | 1.18E−03 | 8.07E−01 | 4.74E−02 | 3.37E−01 | 26 | 1359 | CEBPD, DDX58, B2M, GBP1, BCL2A1, TYROBP, BNIP3L, GBP5, DGAT2, PLIN5, NFKBIA, GLUL, GCA, CCL3, CCL4, PLEK, NOS1, TAP1, ALOX5AP, RILPL2, LCP1, SH2B2, IFIT3, NAMPT, FTL, SOD2 |