Table 1 (abstract REGABS18030). Results from the multilevel analyses. Only significant predictors shown
From: Abstracts from the 2018 Respiratory Effectiveness Group Summit
Hypothesis 1, dependent variable RDAC | Model 1 | |
OR (95% CI) | ||
Characteristics interval level | ||
 Adherence within interval | 1.01 (1.00-1.01)** | |
Characteristics patient level | ||
 Gender (ref=female) | 1.58 (1.34-1.87)*** | |
 Smoking history (ref=current) | ||
  none | 1.47 (1.15-1.89)** | |
  former | 1.61 (1.18-2.19)** | |
 Diagnosed with (ref=no) | ||
  COPD | 0.52 (0.35-0.78)** | |
  CCI (ref=low (≤4)) | 0.65 (0.50-0.85)** | |
  Doses in the device | 1.00 (0.99-1.00)* | |
  Daily dose | 1.07 (1.00-1.15)* | |
The following predictors were found to be non-significant. Characteristics interval level: SABA overuse within interval/lagged, adherence lagged. Characteristics patient level: age, BMI, deprivation, asthma duration, type of ICS device, diagnosed with- rhinitis, allergic rhinitis, hayfever, GERD, other respiratory disease. | ||
Hypothesis 2, dependent variable adherence | Model 1a | Model 2b |
Estimate (SE) | Estimate (SE) | |
Characteristics interval level | ||
 Within same interval | ||
  ≥1 Prescription of antibiotics (ref=no) | -1.77 (0.64)** |  |
  ≥1 Asthma-related outpatient visits (ref=no) | -2.32 (1.17)* |  |
  SABA overuse (ref=no) | -6.68 (0.42)*** | -6.69 (0.42)*** |
  Risk domain asthma control (ref=no) |  | 2.18 (0.46)** |
 Previous interval | ||
  SABA overuse (ref=no) | -1.22 (0.44)** | -1.21 (0.44)** |
Characteristics patient level | ||
 Age | 0.07 (0.01)*** | 0.07 (0.01)*** |
 Deprivation (ref=Q1 most affluent) | ||
  Q2 | 0.94 (0.88) | 0.91 (0.88) |
  Q3 | 2.05 (0.91)* | 2.02 (0.91)* |
  Q4 | 0.51 (0.91) | 0.46 (0.91) |
  Q5 (most deprived) | 0.96 (0.98) | 0.93 (0.98) |
 Diagnosed with (ref=no) | ||
  Hay fever | -2.63 (0.79)*** | -2.62 (0.79)*** |
  COPD | 2.75 (1.10)* | 2.59 (1.10)* |
 Doses in the device | 0.13 (0.0)*** | 0.13 (0.0)*** |
 Daily dose | -3.88 (0.15)*** | -3.87 (0.15)*** |
The following predictors were found to be non-significant. Characteristics interval level, within same interval ≥1: asthma-related hospitalizations, respiratory-related hospitalizations, asthma-related hospitalizations & emergency visits, prescriptions of acute OCS, moderate to severe exacerbations. Characteristics interval level, previous interval ≥1: asthma-related hospitalizations, respiratory-related hospitalizations, asthma-related hospitalizations & emergency visits, prescriptions of acute OCS, prescription of antibiotics, asthma-related outpatient visits, moderate to severe exacerbations, risk domain asthma control. Characteristics patient level: gender, BMI, smoking history, asthma duration, CCI, diagnosed with- rhinitis, allergic rhinitis, GERD, other respiratory disease | ||
a Separate asthma events, both within the same interval as lagged. bOnly composite risk domain asthma control, both within the same interval as lagged. Significance levels: * p<0.05; ** p<0.01; *** p<0.001 | ||