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Table 1 (abstract REGABS18030). Results from the multilevel analyses. Only significant predictors shown

From: Abstracts from the 2018 Respiratory Effectiveness Group Summit

Hypothesis 1, dependent variable RDAC Model 1
OR (95% CI)
Characteristics interval level
 Adherence within interval 1.01 (1.00-1.01)**
Characteristics patient level
 Gender (ref=female) 1.58 (1.34-1.87)***
 Smoking history (ref=current)
  none 1.47 (1.15-1.89)**
  former 1.61 (1.18-2.19)**
 Diagnosed with (ref=no)
  COPD 0.52 (0.35-0.78)**
  CCI (ref=low (≤4)) 0.65 (0.50-0.85)**
  Doses in the device 1.00 (0.99-1.00)*
  Daily dose 1.07 (1.00-1.15)*
The following predictors were found to be non-significant. Characteristics interval level: SABA overuse within interval/lagged, adherence lagged. Characteristics patient level: age, BMI, deprivation, asthma duration, type of ICS device, diagnosed with- rhinitis, allergic rhinitis, hayfever, GERD, other respiratory disease.
Hypothesis 2, dependent variable adherence Model 1a Model 2b
Estimate (SE) Estimate (SE)
Characteristics interval level
Within same interval
  ≥1 Prescription of antibiotics (ref=no) -1.77 (0.64)**  
  ≥1 Asthma-related outpatient visits (ref=no) -2.32 (1.17)*  
  SABA overuse (ref=no) -6.68 (0.42)*** -6.69 (0.42)***
  Risk domain asthma control (ref=no)   2.18 (0.46)**
Previous interval
  SABA overuse (ref=no) -1.22 (0.44)** -1.21 (0.44)**
Characteristics patient level
 Age 0.07 (0.01)*** 0.07 (0.01)***
 Deprivation (ref=Q1 most affluent)
  Q2 0.94 (0.88) 0.91 (0.88)
  Q3 2.05 (0.91)* 2.02 (0.91)*
  Q4 0.51 (0.91) 0.46 (0.91)
  Q5 (most deprived) 0.96 (0.98) 0.93 (0.98)
 Diagnosed with (ref=no)
  Hay fever -2.63 (0.79)*** -2.62 (0.79)***
  COPD 2.75 (1.10)* 2.59 (1.10)*
 Doses in the device 0.13 (0.0)*** 0.13 (0.0)***
 Daily dose -3.88 (0.15)*** -3.87 (0.15)***
The following predictors were found to be non-significant. Characteristics interval level, within same interval ≥1: asthma-related hospitalizations, respiratory-related hospitalizations, asthma-related hospitalizations & emergency visits, prescriptions of acute OCS, moderate to severe exacerbations. Characteristics interval level, previous interval ≥1: asthma-related hospitalizations, respiratory-related hospitalizations, asthma-related hospitalizations & emergency visits, prescriptions of acute OCS, prescription of antibiotics, asthma-related outpatient visits, moderate to severe exacerbations, risk domain asthma control. Characteristics patient level: gender, BMI, smoking history, asthma duration, CCI, diagnosed with- rhinitis, allergic rhinitis, GERD, other respiratory disease
a Separate asthma events, both within the same interval as lagged. bOnly composite risk domain asthma control, both within the same interval as lagged. Significance levels: * p<0.05; ** p<0.01; *** p<0.001
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