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Fig. 7 | Respiratory Research

Fig. 7

From: MUC1 deficiency mediates corticosteroid resistance in chronic obstructive pulmonary disease

Fig. 7

Muc1 KO mice is resistant to the anti-inflammatory effects of dexamethasone in a model of acute cigarette smoke inflammation analysed by micro-CT-PET. C57BL/6 Muc1 KO mice and WT mice were undergoing intranasal instillation of 75 μg of lipopolysaccharide (LPS) at day 1. Between days 2 and 3, animals were exposed to cigarette smoke (or control air) of 6 cigarettes followed by 8 cigarettes (or control air) at days 4 and 5, and 10 cigarettes (or control air) at day 6. Vehicle or dexamethasone at 3 mg/kg/day and 10 mg/kg/day was administered orally once a day between day 1 and 6. Computed tomography (CT) followed by positron emission tomography (PET) of fludeoxyglucose 18F (18F-FDG) was measured as standard uptake value (SUV). Representative images are showed. Results are the mean ± SE of n = 8 animals per experimental group. One-way ANOVA followed by Bonferroni post-hoc tests. *P < 0.05 compared with control. #P < 0.05 compared with LPS/ LPS + CS. KO: knock out; WT: wild type; CS: cigarette smoke; LPS: lipopolysaccharide

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