Fig. 5
From: Serum AGE/RAGEs as potential biomarker in idiopathic pulmonary fibrosis
Correlation between changes in DLCO and differences in sRAGE-AGEs levels in IPF patients. a In IPF patients, a decline of DLCO was related with a decrease of sRAGE in serum (r = 0.555, p < 0.01). b and c On the contrary, AGEs levels and the AGEs/sRAGE ratio were negatively correlated with the percentage of changes in DLCO in IPF patients (r = − 0.747 and − 0704, respectively, p < 0.01), meaning poor lung function in patients with an increase of AGEs-sRAGE imbalance over time. The changes in serum sRAGE and AGEs and lung function from IPF patients was calculated, adjusting over time: Δ ELISA in a month = [ELISA final – ELISA initial]/month; change of % predicted PFT = [PFT final – PFTs initial]/month. Pearson’s correlation coefficients were performed to analyze the lineal relationship between the variables