Table 1 Respiratory manifestations indicating a suspicion of PID in primary care and pulmonology clinics
From: Primary immunodeficiency diseases in lung disease: warning signs, diagnosis and management
Respiratory Manifestions with suspicion of PID in PC | N (Composition of panel) | Votes in agreement (%) | Degree of agreement |
Adult patient | |||
Recurrent bronchial infections (≥ 2/year), with cough and purulent expectoration | 23* (AI, AP) | 87.0 | Consensus |
Idiopathic bronchiectasis | 23* (AI, AP) | 100.0 | Unanimity |
Recurrent pneumonias** | 23* (AI, AP) | 100.0 | Unanimity |
Chronic bronchial infection | 23* (AI, AP) | 91.3 | Consensus |
Need for prolonged antibiotic treatment for respiratory infections | 23* (AI, AP) | 95.7 | Consensus |
Pediatric patient | |||
Recurrent pneumonias** | 19 (PI, PP) | 100.0 | Unanimity |
Idiopathic bronchiectasis | 19 (PI, PP) | 100.0 | Unanimity |
Respiratory manifestations with suspicion of PID in pulmonolgy unit | N (Composition panel) | Votes in agreement (%) | Degree of agreement |
Infections | |||
Adult and pediatric patients | |||
Recurrent bronchial infections (≥ 2/year), with cough and purulent expectoration | 43 (AI, AP, PI, PP) | 86.0 | Consensus |
Idiopathic bronchiectasis | 43 (AI, AP, PI, PP) | 100.0 | Unanimity |
Recurrent pneumonias** | 43 (AI, AP, PI, PP) | 97.7 | Consensus |
Chronic bronchial infection | 43 (AI, AP, PI, PP) | 90.7 | Consensus |
Need for prolonged antibiotic treatment for respiratory infections | 43 (AI, AP, PI, PP) | 93.0 | Consensus |
Pulmonary abscess and pneumatocele | 43 (AI, AP, PI, PP) | 90.7 | Consensus |
Infections caused by rare or opportunistic microorganisms | 43 (AI, AP, PI, PP) | 100.0 | Unanimity |
Infants | |||
Severe infantile bronchiolitis or pneumonia | 43 (AI, AP, PI, PP) | 93.0 | Consensus |
NON-INFECTIOUS | |||
Adult and pediatric patients | |||
Granulomatous-lymphocytic interstitial lung disease | 43 (AI, AP, PI, PP) | 100.0 | Unanimity |
Bronchiolitis obliterans | 43 (AI, AP, PI, PP) | 72.1 | Majority |
Lymphoproliferative syndrome | 43 (AI, AP, PI, PP) | 90.7 | Consensus |
Alveolar proteinosis | 43 (AI, AP, PI, PP) | 86.0 | Consensus |
Recurrent serositis | 43 (AI, AP, PI, PP) | 76.7 | Majority |
Thymic disorders: thymoma (adult), thymic aplasia (infant) | 43 (AI, AP, PI, PP) | 100.0 | Unanimity |