From: Therapeutic potential of products derived from mesenchymal stem/stromal cells in pulmonary disease
CM Source | Route | Injury Model | Outcomes | Key Factor | Ref. |
---|---|---|---|---|---|
Mouse BM-MSC | IT | Mouse-ALI/LPS | ↓ Neutrophils in BALF ↑ M2 in BALF | IGF-1 | [74] |
Human BM-MSC | IV | Rat-Pneumonia/E. coli | ↑ Survival | LL-37 | [81] |
Rat BM-MSC | IT | Rat-Lung Injury/I/R | ↓ Pro-inflammatory cytokines ↓ Neutrophils in BALF ↑ M2 & Treg in BALF | [82] | |
Mouse BMC | IN | Mouse-Asthma/OVA | ↓ Airway inflammation ↓ Airway hyper-responsiveness ↓ Airway smooth muscle thickness ↑ IL-10 producing Treg & macrophages | APN | [83] |
Mouse BM-MSC | IV | Neonatal Mouse-BPD/Hyperoxia | ↓ Right ventricular hypertrophy ↓ Intrapulmonary arterioles muscularization ↓ Inflammatory cells & cytokines in BALF Preserve alveoli morphology ↑ Number of BASCs | Opn Csf1 | |
Hyperoxia Preconditioned Rat BM-MSC | IP | Neonatal Rat- BPD/Hyperoxia | ↓ PAH ↓ Right ventricular hypertrophy ↓ Pulmonary artery medial wall thickness Improved lung structure | STC-1 | [87] |
Rat BM-MSC | IT | Rat-Lung Fibrosis/ Bleomycin | ↓ Lung fibrosis ↓ AEC apoptosis | [76] | |
Rat BM-MSC | IV | Rat-COPD/ cigarette smoke | ↓ Lung emphysema ↓ Pulmonary artery medial wall thickness ↑ Number of small pulmonary vessels Protect lung fibroblasts |