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Table 1 Bioactive factors secreted by MSCs directly in CM or via EVs

From: Therapeutic potential of products derived from mesenchymal stem/stromal cells in pulmonary disease

Angiogenesis

Anti-apoptosis

Anti-fibrosis

Anti-oxidation

Chemo-attraction

Immuno- modulation

Proliferation

Ang1

FGF

Ang-1

HO-1

CCLs

HO-1

FGF

FGF

GM-CSF

FGF

IL-1β

CXCLs

IDO

HGF

HGF

HGF

HGF

STC-1

G-CSF

IL-1ra

IGF-1

IGF-1

IGF-1

KGF

 

LIF

IL-6

KGF

IL-6

IL-6

MMPs

 

M-CSF

IL-10

PDGF

MCP-1

STC-1

TIMP-1

 

MCP-1

LIF

VEGF

PDGF

   

SDF-1

PGE2

 

VEGF

    

STC-1

 
     

TGF-β

 
     

TSG-6

 
  1. Ang-1 – angiopoietin 1, CCL – chemokine ligand, CXCL – chemokine (C-X-C motif) ligand, FGF – fibroblast growth factor, GM-CSF – granulocyte monocyte colony stimulating factor, HGF – hepatocyte growth factor, HO-1 – hemeoxygenase 1, IDO – indoleamine 2,3-dioxygenase, IGF-1 – insulin like growth factor 1, IL – interleukin, IL-1ra – IL-1 receptor antagonist, KGF – keratinocyte growth factor, LIF – leukemia inhibitory factor, LL-37 – human cathelicidin, MMP – metalloproteinase, MCP-1 – monocyte chemoattractant protein 1, PDGF – platelet derived growth factor, PGE2 – prostaglandin E2, SDF-1 – stem cell-derived factor 1, STC-1 – stanniocalcin 1, TIMP-1 – tissue inhibitor of metalloproteinase 1, TGF-β – transforming growth factor beta, TSG-6 – tumor necrosis factor-stimulated gene 6, VEGF – vascular endothelial growth factor