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Table 1 Bioactive factors secreted by MSCs directly in CM or via EVs

From: Therapeutic potential of products derived from mesenchymal stem/stromal cells in pulmonary disease

Angiogenesis Anti-apoptosis Anti-fibrosis Anti-oxidation Chemo-attraction Immuno- modulation Proliferation
Ang1 FGF Ang-1 HO-1 CCLs HO-1 FGF
FGF GM-CSF FGF IL-1β CXCLs IDO HGF
HGF HGF HGF STC-1 G-CSF IL-1ra IGF-1
IGF-1 IGF-1 KGF   LIF IL-6 KGF
IL-6 IL-6 MMPs   M-CSF IL-10 PDGF
MCP-1 STC-1 TIMP-1   MCP-1 LIF VEGF
PDGF     SDF-1 PGE2  
VEGF      STC-1  
      TGF-β  
      TSG-6  
  1. Ang-1 – angiopoietin 1, CCL – chemokine ligand, CXCL – chemokine (C-X-C motif) ligand, FGF – fibroblast growth factor, GM-CSF – granulocyte monocyte colony stimulating factor, HGF – hepatocyte growth factor, HO-1 – hemeoxygenase 1, IDO – indoleamine 2,3-dioxygenase, IGF-1 – insulin like growth factor 1, IL – interleukin, IL-1ra – IL-1 receptor antagonist, KGF – keratinocyte growth factor, LIF – leukemia inhibitory factor, LL-37 – human cathelicidin, MMP – metalloproteinase, MCP-1 – monocyte chemoattractant protein 1, PDGF – platelet derived growth factor, PGE2 – prostaglandin E2, SDF-1 – stem cell-derived factor 1, STC-1 – stanniocalcin 1, TIMP-1 – tissue inhibitor of metalloproteinase 1, TGF-β – transforming growth factor beta, TSG-6 – tumor necrosis factor-stimulated gene 6, VEGF – vascular endothelial growth factor