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Table 4 Risk ratios for 10-Year CVD Risk according to lung function parameters (N = 1071)

From: Association of lung function with cardiovascular risk: a cohort study

Variables

RRs (95% CI) by Continuous lung functiona

RRs (95% CI) by groups of lung function parameters

p trend

FEV1/FVC (%)

 

L4 (≥90)

L3 (80 ~ < 90)

L2 (70 ~ < 80)

L1 (< 70)

 

 N (≥10% / < 10%)

214/857

82/377

90/361

33/110

9/9

 

 Adjusted RR (95% CI)

1.14 (1.03, 1.25)

1.00 (ref.)

1.15 (0.80, 1.65)

1.41 (0.85, 2.34)

4.06 (1.46, 11.26)

0.021

FVC (L)

 

Q4 (> 2.8)

Q3 (2.5~ 2.8)

Q2 (2.1~ 2.4)

Q1 (≤2.0)

 

 N (≥10% / < 10%)

214/857

60/197

29/211

61/266

64/183

 

 Adjusted RR (95% CI)

1.04 (1.02, 1.06)

1.00 (ref.)

1.10 (0.58, 2.10)

2.07 (1.11, 3.85)

3.19 (1.68, 6.06)

< 0.001

FEV1 (L)

 

Q4 (> 2.5)

Q3 (2.2~ 2.5)

Q2 (1.9~ 2.1)

Q1 (≤1.8)

 

 N (≥10% / < 10%)

214/857

46/180

43/235

49/243

76/199

 

 Adjusted RR (95% CI)

1.07 (1.05, 1.09)

1.00 (ref.)

2.46 (1.28, 4.76)

3.33 (1.63, 6.81)

6.49 (3.19, 13.18)

< 0.001

  1. Abbreviations: FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity; FEV1/FVC, the ratio of FEV1 to FVC; RR, risk ratio; CI, confidence interval
  2. Adjusted for gender (male/female), height (continuous, m), weight (continuous, kg), abdominal obesity (yes/no), smoking amount (continuous, pack-year), drinking status (drinker/nondrinker), low density lipoprotein (continuous, mmol/L), physical activity (active/inactive), city (Wuhan/Zhuhai) and education levels (middle school or below, high school, university or above)
  3. aRisk ratios were estimated by each 5% decrease of FEV1/FVC or each 50-mL decrease of FVC or FEV1 in continuous analyses
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Respiratory Research

ISSN: 1465-993X

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