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Fig. 8 | Respiratory Research

Fig. 8

From: Dietary ω-6 polyunsaturated fatty acid arachidonic acid increases inflammation, but inhibits ECM protein expression in COPD

Fig. 8

Reduced basal fibronectin, type I collagen, tenascin and perlecan deposition upon arachidonic acid challenge. Pulmonary fibroblasts from COPD (n = 5–6) and non-COPD patients (n = 4–5) were unstimulated (control) or challenged with the ω-6 PUFA arachidonic acid (AA) in 0.1% BSA-DMEM (100 μM) for 72 h. Deposition of fibronectin (a), type I collagen (b), tenascin (c) and perlecan (d) into the extracellular matrix (ECM) was measured by ECM ELISA. All data are expressed at fold change compared to control ± standard error of the mean. Challenge with AA is compared to control using a Two-way ANOVA with LSD fisher’s test. Significance is represented as * (p < 0.05), ** (p < 0.01), *** (p < 0.001) or **** (p < 0.0001)

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