Table 1 Model inputs: baseline demographics by base case and ITT population, and resource costs

Female, %

19.2 [34]

39.8

Age (years), mean (SE)

68.2 (0.4) [34]

64.4 (0.6)

Smoking status (current smokers), %

23.1 [35]

53.0

Any cardiovascular comorbidity, %

26.3^a

26.3^b

Any other comorbidity, %

78.4^a

78.4

History of exacerbation, ≥1 moderate or severe in the previous 12 months, %

18.2^a

18.2

  < 21

7.1 [35]

10

 21–30

60.8 [35]

50

  > 30

32.1 [35]

40

mMRC score ≥ 2, %

100^a

100

Number of moderate and severe exacerbations in previous year, mean (SE)

0.2 (0.03)^a

0.2 (0.03)

Number of severe exacerbations in previous year as a % of total previous year exacerbations, mean

13.7^a

13.7

Baseline FEV₁% predicted, mean (SD)

59.6 (5.6)^a

59.6 (5.6)

Baseline FEV₁ mL, mean (SE)

1563 (28.6)^a

1563 (28.6)

Height (cm), mean (SE)

167.6 (0.3) [36]

169.9 (0.6)

Fibrinogen (mcg/dL), mean

456.7^c

453.2^c

SGRQ score, mean (SE)

42.7 (0.3) [56]

43.1 (1.0)^d

6MWT distance (m), mean

346.1^c

349.9^c

 Moderate exacerbation

 Severe exacerbation

 Without dyspnea symptoms

 With dyspnea symptoms several days per week

 With dyspnea symptoms most days per week