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Fig. 6 | Respiratory Research

Fig. 6

From: Selective activation and proliferation of a quiescent stem cell population in the neuroepithelial body microenvironment

Fig. 6

Comparison of the distribution of BrdU-labeled (red Cy3 fluorescence) airway epithelial cells 48 h after LPS challenge of WT-Bl6 (a, b) and GAD67-GFP mice (c, d). a, c Clustered BrdU-positive nuclei (open arrowheads) can be observed at distinct locations in the airway epithelium. Combination with CGRP immunostaining (b; green FITC fluorescence) for WT-Bl6 mice, or visualization of GFP-fluorescent NEB cells (d) in GAD67-GFP mice, reveals that the majority of divided cells that have incorporated BrdU are found in the immediate neighborhood of NEBs. No obvious differences can be seen between WT-Bl6 and GAD67-GFP mice. Note that only very occasionally, a BrdU-positive nucleus can be seen in a NEB cell (arrow; a, b). L: airway lumen, E: airway epithelium

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