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Table 4 Uni- and multivariate regression analysis of RV output reserve

From: Right heart size and function significantly correlate in patients with pulmonary arterial hypertension – a cross-sectional study

Univariate analysis (∆ CI Peak)

n

pearson’s R

p-value

 

Age

54

0.424

0.001

*

 Body mass index

54

0.092

0.506

 

 6 min walking distance

54

0.278

0.044

*

 NT-proBNP

54

- 0.360

0.008

*

Echocardiography

 Systolic pulmonary arterial pressure

54

- 0.462

< 0.001

*

 Right atrial area

54

- 0.313

0.021

*

 Right ventricular area

54

- 0.376

0.005

*

 Tricuspid annular plane systolic excursion

54

0.065

0.64

 

Cardiopulmonary exercise testing

 peak oxygen consumption (V’O2)

54

0.466

< 0.001

*

 peak oxygen consumption/kg (V’O2/kg)

54

0.380

0.005

*

Right heart catheter

rest

 mean pulmonary arterial pressure

54

- 0.288

0.035

*

 Cardiac Output

54

0.282

0.039

*

 Cardiac Index

54

0.223

0.106

 

 Pulmonary arterial wedge pressure

54

- 0.016

0.906

 

 pulmonary vascular resistance

54

- 0.366

0.006

*

exercise

 mean pulmonary arterial pressure

54

- 0.073

0.598

 

 Cardiac Output

54

0.839

< 0.001

*

 Cardiac Index

54

0.894

< 0.001

*

Lung function / Diffusing capacity

 DLCOc SB

48

0.361

0.012

*

 DLCOc / VA

48

0.342

0.017

*

Multivariate analysis

Logistic Regression (stepwise forward selection)

 ∆ CI exrcise (dichotomous)

 

Exp (B)

  

 Right ventricular area

47

0.863

0.027

*

Linear Regression (stepwise forward selection)

 ∆ CI Peak (continuous)

 

pearson’s R

  

 Right ventricular area

47

- 0.360

0.003

*

 Age

47

- 0.412

0.001

*

  1. CI = Cardiac Index, NT-proBNP = N-terminal pro brain natriuretic peptide, DLCOc SB = diffusing capacity transfer factor, DLCOc / VA = diffusing capacity transfer coefficient
  2. * = significant at level 0.05, Exp (B) = Regression coefficient