Table 1 Secondary Outcomes
Clinical Outcome | No of Trials (number of patients) | Summary Estimate of Effect (Risk Ratio/Mean Difference with 95% CI) | P-value | I2 (%) |
|---|---|---|---|---|
Trials Comparing HFNC vs. COT as an Initial Support Strategy | ||||
 ICU mortality | 1(200)a | – | – | – |
 Hospital mortality | 2(503) | 0.72(0.42–1.25) | 0.25 | 59% |
 ICU length of stay | – | – | – | – |
 Hospital length of stay | – | – | – | – |
 ED length of stay | 3(531)b | – | – | – |
Trials Comparing HFNC vs. COT After Extubation | ||||
 ICU mortality | 3(787) | 0.99(0.47–2.08) | 0.97 | 0% |
 Hospital mortality | 2(683) | 0.87(0.47–1.58) | 0.64 | 0% |
 ICU length of stay | 4(710) | 3.06(−0.56–6.69) | 0.10 | 0% |
 Hospital length of stay | 1(59)a | – | – | – |
 ED length of stay | – | – | – | – |
Trials Comparing HFNC vs. NIV as an Initial Support Strategy | ||||
 ICU mortality | 1(216)a | – | – | – |
 Hospital mortality | – | – | – | – |
 ICU length of stay | – | – | – | – |
 Hospital length of stay | – | – | – | – |
 ED length of stay | 1(204)a | – | – | – |
Trials Comparing HFNC vs. NIV After Extubation | ||||
 ICU mortality | 2(1434) | 1.20(0.87–1.85) | 0.40 | 0% |
 Hospital mortality | – | – | – | – |
 ICU length of stay | 1(604)a | – | – | – |
 Hospital length of stay | – | – | – | – |
 ED length of stay | – | – | – | – |