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Fig. 3 | Respiratory Research

Fig. 3

From: Upregulation of microRNA-17-5p contributes to hypoxia-induced proliferation in human pulmonary artery smooth muscle cells through modulation of p21 and PTEN

Fig. 3

miR-17-5p plays a role in PASMC migration. a-d miR-17-5p overexpression led to increased PASMC migration as measured by time-lapse microscopy. PASMCs were cultured in Ibidi culture inserts. Compared with the negative controls, cells overexpressing miR-17-5p showed a 16% increase in migration at 12 h (B1-B2). Compared with the control treatment, inhibition of miR-17-5p via transfection with an miR-17-5p antagomir caused a 10% decrease in migration at 12 h (B1, B3). c Change in the cell-covered area over time. d PASMC migration after 10 h, 12 h, and 14 h. The values are expressed as the means ± SD of three independent experiments, and in each experiment, three parallel samples were analysed per group. *P < 0.05, #P < 0.01

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Respiratory Research

ISSN: 1465-993X

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