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Fig. 6 | Respiratory Research

Fig. 6

From: Antiestrogen- and tamoxifen-induced effects on calcium-activated chloride currents in epithelial cells carrying the ∆F508-CFTR point mutation

Fig. 6

Effect of ivacaftor (VX-770) and lumacaftor (VX-809) on current density of CFBE cells. a example of current/voltage relationship of cells in control conditions (squares), in the presence of 1 μM VX-770 and 3 μM VX-809 (circles) and after addition of 10 μM forskolin (triangles). Addition of the CFTR ion channel blocker Inh-172 reduced the transmembrane current almost to that occurring in control conditions (diamonds). b chart plot of membrane current density at + 80 mV relative to the value of the current in control conditions (n = 11), stimulated by VX-770 and VX-809 (n = 8) and after the addition of forskolin (n = 8) compared to current inhibitor Inh-172 (n = 4; p ≥ 0.001)

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Respiratory Research

ISSN: 1465-993X

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