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Fig. 5 | Respiratory Research

Fig. 5

From: Antiestrogen- and tamoxifen-induced effects on calcium-activated chloride currents in epithelial cells carrying the ∆F508-CFTR point mutation

Fig. 5

Effect of TMX and ATP on current density in CFBE cells. a example of current/voltage relationship of cells in control conditions (squares), in the presence of 10 μM TMX (circles) and after addition of 100 μM ATP (triangles). b example of current/voltage relationship of cells in control conditions (squares), and in the presence of 10 μM TMX + 100 μM ATP (circles). Membrane current stimulated by TMX + ATP was almost totally inhibited by 300 μM NPPB (triangles). c plot of membrane current density expressed as a percentage of increase at + 80 mV relative to the value of the current in control conditions (n = 15; p ≥ 0.001). TMX in combination with ATP (n = 10) produced a significant increment compared with TMX stimulation alone (n = 11; p ≥ 0.05). Addition of NPPB completely inhibited the current (n = 6)

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Respiratory Research

ISSN: 1465-993X

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