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Fig. 2 | Respiratory Research

Fig. 2

From: Antiestrogen- and tamoxifen-induced effects on calcium-activated chloride currents in epithelial cells carrying the ∆F508-CFTR point mutation

Fig. 2

Effect of 17β-estradiol, ATP and tamoxifen (TMX) on CFBE single cell membrane current density. a current/voltage relationship of control cells (squares; n = 15) and in the presence of the chloride channel blocker NPPB 300 μM (triangles; n = 4). b current density versus membrane voltages in control cells (squares; n = 15) in the presence of 10 nM 17β-estradiol (triangles; n = 5) or 100 μM ATP (circles; n = 6). ATP (100 μM) was not able to increase current density once in combination with 10 nM 17β-estradiol (diamonds; n = 6). c current/voltage relationship of control cells (squares; n = 15), after perfusion with 10 μM TMX (circles; n = 7). The addition of 100 μM ATP induced a marked increase of current density (triangles; n = 6). d and e current density box chart plots at + 80 mV membrane voltage related to the experiments reported in B and C

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Respiratory Research

ISSN: 1465-993X

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