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Table 4 Associations with NHGRI-EBI asthma SNPs in COPDGene childhood asthma GWAS

From: Childhood asthma is associated with COPD and known asthma variants in COPDGene: a genome-wide association study

NHW a

Gene

SNP

Locus

Effect Allele

OR

Rsq

Freq (%)

P-value b,d

Adj P-value e

(385 cases, 4979 controls)

IL1RL1

rs10197862 f

2q12.1

A

1.45

1.00

0.85

0.002

0.011

 

TSLP

rs1837253g

5q22.1

T

1.07

 

0.75

0.414

1.000

 

RAD50

rs2244012f

5q31.1

G

1.05

 

0.78

0.579

1.000

 

IL13

rs1295686f

5q31.1

T

1.22

 

0.80

0.026

0.180

 

C11orf30-LRRC32

rs7130588g

11q13.5

G

1.23

 

0.64

0.008

0.054

 

GSDMB

rs2305480f

17q21.1

G

1.22

 

0.44

0.009

0.060

 

GSDMA

rs3894194f

17q21.1

A

1.18

0.94

0.47

0.029

0.201

AA a

Gene

SNP

Locus

Effect Allele

OR

Rsq

Freq (%)

P-value b,d

Adj P-value e

(325 cases, 2342 controls)

IL1RL1

rs10197862f

2q12.1

A

1.10

0.98

0.74

0.344

1.000

 

TSLP

rs1837253g

5q22.1

C

1.11

 

0.28

0.283

1.000

 

RAD50

rs2244012f

5q31.1

G

1.05

 

0.57

0.603

1.000

 

IL13

rs1295686f

5q31.1

T

1.16

 

0.64

0.102

0.717

 

C11orf30-LRRC32

rs7130588g

11q13.5

G

1.23

 

0.80

0.035

0.247

 

GSDMB

rs2305480f

17q21.1

G

1.03

 

0.13

0.817

1.000

 

GSDMA

rs3894194f

17q21.1

G

1.02

0.88

0.69

0.846

1.000

Meta-analysis a

Gene

SNP

Locus

Effect Allele

OR

I 2

 

P-value c,d

Adj P-value e

(710 cases, 7321 controls)

IL1RL1

rs10197862 f

2q12.1

A

1.23

70

 

0.006

0.042

 

TSLP

rs1837253g

5q22.1

C

1.01

45

 

0.910

1.000

 

RAD50

rs2244012f

5q31.1

G

1.05

0

 

0.447

1.000

 

IL13

rs1295686 f

5q31.1

T

1.19

0

 

0.006

0.043

 

C11orf30-LRRC32

rs7130588 g

11q13.5

G

1.23

0

 

0.001

0.005

 

GSDMB

rs2305480f

17q21.1

G

1.17

27

 

0.018

0.125

 

GSDMA

rs3894194f

17q21.1

A

1.10

57

 

0.113

0.794

  1. Abbreviations: NHGRI-EBI National Human Genome Research Institute - European Bioinformatics Institute; SNP single nucleotide polymorphism; GWAS genome-wide association study; NHW Non-Hispanic Whites; AA African American; OR odds ratio of the effect allele; Rsq estimation of imputation quality; Freq frequency of effect allele; I2 heterogeneity index; a Each population was run as an independent analysis, and then combined in the meta-analysis: b Logistic regression based on case control status; c Fixed effect meta-analysis weighted by inverse variance. d Adjusted for sex, genetic ancestry. e Bonferroni correction for seven tests, SNPs with adjusted p < 0.05 in Bold. f SNP is in the reported gene, g SNP is near the reported gene
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Respiratory Research

ISSN: 1465-993X

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