Childhood asthma is associated with COPD and known asthma variants in COPDGene: a genome-wide association study

Respiratory Research

Table 2 COPD and lung function in subjects with childhood asthma compared to never asthma subjects

	Childhood	Never	Impact of Childhood Asthma
	Asthma	Asthma
	N = 730	N = 7493	OR	95% CI	P-value^a
COPD (%)^{b,d, e}	341 (47%)	2303 (31%)	3.42	(2.81, 4.18)	< 0.001
COPD (%)^{b,d, e}			β	SE	P-value
FEV₁ post-bronchodilator % predicted (SD)^c,d	69% (25)	80% (26)	−10.44	0.92	< 0.001
FVC post-bronchodilator % predicted (SD)^c,d	83% (19)	89% (18)	−6.01	0.68	< 0.001
FEV₁/FVC post-bronchodilator (SD)^c,d,e,f	0.64 (0.16)	0.68 (0.16)	−0.06	0.01	< 0.001

Abbreviations: COPD chronic obstructive pulmonary disease; FEV₁ forced expiratory volume in the first second; SD standard deviation; FVC forced vital capacity. ^aEach row is a separate model: ^bLogistic regression with odds ratio (OR), 95% confidence interval (CI); ^cLinear regression with beta coefficient (β), standard error (SE). Covariates: ^dpack years; ^egender, age at enrollment, race; ^fheight

ISSN: 1465-993X