Fig. 6

Individual data for change in visual analogue scale for air hunger (AH) and work/effort (WE). Individual change in visual analogue scale ratings (VAS, % full scale) of AH at fixed test levels of PETCO₂ (left panel), and of the sense of breathing WE at fixed test levels of tidal volume (right panel) following inhaled furosemide (dark bars) and inhaled saline (grey bars). Closed bars indicate the average change in VAS for two furosemide inhalations in half the participants (S1, 2, 4, 7, 10, 11, 14, 17) or the change in VAS for one furosemide inhalation in the other half. Open bars indicate the average change in VAS for two saline inhalations in half the participants (S3, 5, 6, 8, 9, 12, 13, 15) or the change in VAS for one saline inhalation in the other half. Inhalation of furosemide tends to produce a reduction in VAS after furosemide more often than after saline for the AH test. For WE test reductions were evident for both inhaled furosemide and inhaled saline. Participants are arranged in order of response to furosemide for the AH test