Fig. 5From: Inhaled furosemide for relief of air hunger versus sense of breathing effort: a randomized controlled trialOverall changes in air hunger (AH) and work/effort (WE) associated with mist inhalations. Panel a. Mean ± SEM AH (left panels) and WE (right panels) before and after furosemide inhalations (black bars) and before and after saline inhalations (grey bars) in the 8 individuals who were allocated to the saline-furosemide-saline order of mist inhalations (top panels) and in 8 individuals who were allocated to the furosemide-saline-furosemide order of mist inhalations (bottom panels). VAS ratings improved to a greater extent after furosemide compared to saline mist inhalations for AH, but this pattern was not evident for WE. ETCO2 = end tidal CO2 (mean ± SD mmHg). Panel b. Least Squares Mean change in VAS ratings before and after inhaled furosemide relative to the change before and after inhaled saline for AH and WEBack to article page