Fig. 3

Effect of mist inhalations on steady state air hunger (AH) and work/effort (WE). This dataset is from an individual who received the mists in the order of furosemide-saline-furosemide (FSF) with the corresponding saline-furosemide-saline (SFS) intravenous infusions on both days. Panels a to f show the last minute of each test level of end-tidal CO₂ (for AH) or of VT (for WE) –these regions of interest are shown by the vertical dashed lines in Fig. 2. AH test day: Air hunger ratings were reduced after furosemide inhalation (a to b and e to f) but not after saline inhalation (c to d). WE test day: No obvious differences in ratings were evident before and after any mist inhalations