| Control | Rehabilitation | Rehabilitation effect mean (95% CI ll,ul) | p- Value |
---|---|---|---|---|
6MWD (m) | ||||
 Baseline | 491 (57) | 462 (57) |  | 0.36 |
 3 months | 474 (57) | 504 (57) | 59 (33, 85) | < 0.001 |
 6 months | 468 (57) | 511 (57) | 72 (36, 108) | < 0.001 |
 1 year | 456 (57) | 501 (57) | 73 (28, 118) | 0.002 |
Wmax (%pred) | ||||
 Baseline | 71 (18) | 61 (18) |  | 0.15 |
 3 months | 68 (18) | 68 (18) | 10 (2, 19) | 0.01 |
 6 months | 62 (18) | 71 (18) | 19 (8, 29) | < 0.001 |
 1 year | 61 (18) | 74 (18) | 23 (10, 35) | < 0.001 |
SVC (%pred) | ||||
 Baseline | 77 (21) | 76 (21) |  | 0.86 |
 3 months | 77 (21) | 78 (21) | 2 (−2, 6) | 0.23 |
 6 months | 75 (21) | 77 (21) | 3 (−1, 7) | 0.20 |
 1 year | 76 (21) | 79 (21) | 4 (−0.2, 9) | 0.06 |
DLCO (%pred) | ||||
 Baseline | 42 (13) | 45 (13) |  | 0.31 |
 3 months | 39 (13) | 44 (13) | 1.2 (− 2.4, 4.8) | 0.52 |
 6 months | 39 (13) | 43(13) | 0.9 (−3.6, 5.3) | 0.70 |
 1 year | 38 (13) | 45 (13) | 3.2 (−1.8, 8.2) | 0.21 |
QF (%pred) | ||||
 Baseline | 81 (27) | 78 (27) |  | 0.69 |
 3 months | 81 (27) | 88 (27) | 10 (2, 18) | 0.01 |
 6 months | 83 (27) | 90 (27) | 10 (1, 18) | 0.02 |
 1 year | 88 (27) | 94 (27) | 9.5 (1, 18) | 0.04 |
HF (%pred) | ||||
 Baseline | 73 (17) | 76(17) |  | 0.56 |
 3 months | 76 (17) | 91 (17) | 12.5 (5, 20) | 0.002 |
 6 months | 75 (17) | 90 (17) | 12 (4, 20) | 0.004 |
 1 year | 79 (17) | 88 (17) | 6 (−3, 15) | 0.20 |
SGRQ total | ||||
 Baseline | 40 (14) | 42 (14) |  | 0.68 |
 3 months | 44 (14) | 39 (14) | −7 (−13, −2) | 0.005 |
 6 months | 46 (14) | 35 (14) | −12 (−19, −6) | < 0.001 |
 1 year | 45 (14) | 35 (14) | −11 (− 18, −4) | 0.002 |