The moderate predictive value of serial serum CRP and PCT levels for the prognosis of hospitalized community-acquired pneumonia

Table 5 Prognostic performance of Biomarkers and CURB-65 in predicting pneumonia prognosis

Variable(s)	AUC	SE	P value	95%CI
CRP1 (mg/L)	0.45	0.05	0.37	0.36-0.55
CRP3 (mg/L)	0.69	0.05	<0.001	0.6-0.8
CRP3c	0.77	0.04	<0.001	0.7-0.85
CRP5(mg/L)	0.76	0.05	<0.001	0.67-0.85
CRP5c	0.81	0.03	<0.001	0.75-0.87
PCT1 (ng/mL)	0.57	0.05	0.11	0.49-0.67
PCT3 (ng/mL)	0.61	0.05	0.02	0.52-0.71
PCT3c	0.57	0.04	0.13	0.49-0.66
PCT5 (ng/mL)	0.73	0.04	<0.001	0.65-0.82
PCT5c	0.65	0.05	<0.001	0.57-0.75
CRP1*PCT1	0.55	0.05	0.36	0.45-0.65
CRP3*CRP3c	0.7	0.05	<0.001	0.6-0.8
CRP5*CRP5c	0.77	0.05	<0.001	0.68-0.86
PCT3*PCT3c	0.65	0.04	<0.001	0.56-0.74
PCT5*PCT5c	0.74	0.04	<0.001	0.66-0.83
CRP3*PCT3	0.7	0.05	<0.001	0.6-0.81
CRP3c*PCT3c	0.76	0.04	<0.001	0.68-0.84
CRP5*PCT5	0.79	0.04	<0.001	0.71-0.87
CRP5c*PCT5c	0.67	0.04	<0.001	0.58-0.76
CRP5CRP5cPCT5*PCT5c	0.79	0.04	<0.001	0.71-0.87
CRP3CRP3c CRP5*CRP5c	0.85	0.04	<0.001	0.77-0.92
PCT3PCT3cPCT5*PCT5c	0.81	0.04	<0.001	0.73-0.9
CRP3CRP3c CRP5CRP5c PCT3PCT3cPCT5*PCT5c	0.81	0.04	<0.001	0.73-0.88
CURB-65	0.53	0.05	0.53	0.44-0.63
CRP3CRP3cCRP5CRP5cCURB-65	0.77	0.04	<0.001	0.69-0.85
PCT3PCT3cPCT5PCT5cCURB-65	0.72	0.05	<0.001	0.64-0.81

^aUnder the nonparametric assumption
^bNull hypothesis: true area = 0.5
^cROC receiver operating characteristic, AUC area under the curve, SE standard error, CI confidence interval

ISSN: 1465-993X