Table 3 Risk of pneumonia by type of treatment (FP, other ICS, no ICS use) at baseline
Treatment at baseline | Comparison | |||||
|---|---|---|---|---|---|---|
FP | Other ICS | No ICS | FP versus other ICS HR* or RR† (95% CI); p-value | FP versus no ICS HR* or RR† (95% CI); p-value | Other ICS versus no ICS HR* or RR† (95% CI); p-value | |
Use at baseline, n | 1334 | 1334 | 1334 | – | – | – |
Patients with pneumonia event, n (%)# | 207 (15.5) | 184 (13.8) | 169 (12.7) | HR 1.20 (0.99, 1.47); p = 0.067 | HR 1.30 (1.06, 1.59); p = 0.012 | HR 1.08 (0.88, 1.33); p = 0.467 |
Pneumonia events, n | 286 | 220 | 214 | – | – | – |
Adjusted rate of pneumonia events (per patient-year), mean (95% CI) | 0.10 (0.08, 0.12) | 0.07 (0.06, 0.09) | 0.07 (0.05, 0.09) | RR 1.35 (1.05, 1.74); p = 0.020 | RR 1.37 (1.06, 1.78); p = 0.015 | RR 1.02 (0.77, 1.34); p = 0.907 |
Patients with hospitalized pneumonia events, n (%) | 140 (10.5) | 114 (8.5) | 100 (7.5) | HR 1.31 (1.02, 1.68); p = 0.032 | HR 1.48 (1.14, 1.91); p = 0.003 | HR 1.13 (0.86, 1.47); p = 0.382 |
Hospitalized pneumonia events, n | 172 | 133 | 121 | – | – | – |
Adjusted rate of hospitalized pneumonia events (per patient-year), mean (95% CI) | 0.06 (0.04, 0.08) | 0.04 (0.03, 0.06) | 0.04 (0.03, 0.05) | RR 1.34 (0.99, 1.81); p = 0.055 | RR 1.46 (1.07, 1.98); p = 0.016 | RR 1.09 (0.79, 1.51); p = 0.607 |
Patients with pneumonia resulting in death, n (%) | 8 (0.60) | 18 (1.35) | 15 (1.12) | HR 0.46 (0.20, 1.05); p = 0.066 | HR 0.55 (0.23, 1.30); p = 0.174 | HR 1.20 (0.61, 2.39); p = 0.595 |