From: Serum sST2 levels predict severe exacerbation of asthma
Stable | At-risk | P-value*† | |
---|---|---|---|
(N = 93) | (N = 11) | ||
Age, mean (SD) | 52.7 (15.4) | 51.7 (19.4) | 0.852 |
Sex, M: F, n (%) | 39 (42.0): 54 (58.0) | 3 (27.3): 8 (72.7) | 0.540 |
BMI, median (IQR) | 22.9 (20.6–26.9) | 24.6 (21.8–30.1) | 0.089 |
Smoking, n (%) | |||
Current-smoker | 8 (8.6) | 2 (18.2) | 0.454 |
Ex-smoker | 27 (29.0) | 4 (36.4) | |
Never-smoker | 58 (62.4) | 5 (45.4) | |
Asthma control, n (%) | |||
Well controlled | 29 (31.2) | 1 (9.1) | < 0.001 |
Partially controlled | 51 (54.8) | 2 (18.2) | |
Uncontrolled | 13 (14.0) | 8 (72.7) | |
Treatment step, n (%) | |||
1 | 4 (4.3) | 0 (0.0) | 0.008 |
2 | 14 (15.1) | 0 (0.0) | |
3 | 20 (21.5) | 0 (0.0) | |
4 | 49 (52.7) | 7 (63.6) | |
5 | 6 (6.4) | 4 (36.4) | |
Oral CS use, n (%) | 6 (6.5) | 4 (36.4) | 0.011 |
Laboratory tests | |||
WBC (/μL), median (IQR) | 6300 (5000–7200) | 10,500 (6700–12,100) | < 0.001 |
Neutrophil (/μL), median (IQR) | 3618 (2745–4772) | 8159 (3953–9196) | < 0.001 |
Eosinophil (/μL), median (IQR) | 201 (128–334) | 79 (32–303) | 0.029 |
CRP (mg/dl), median (IQR) | 0.1 (0–0.2) | 0.1 (0–0.5) | 0.208 |
IgE (IU/ml), median (IQR) | 188 (45–533) | 185 (12–1539) | 0.841 |
IL-8 (pg/ml), median (IQR) | 13.1 (10.6–16.9) | 16.0 (9.6–22.6) | 0.612 |
IL-6 (pg/ml), median (IQR) | 1.0 (0.5–1.7) | 2.4 (1.2–3.7) | 0.035 |
Serum H2O2 (U.CARR), median (IQR) | 336 (302–380) | 379 (350–421) | 0.025 |
FeNO (ppb), median (IQR) | 24 (16–42) | 16 (11–99) | 0.302 |
EBC H2O2 (U.CARR), median (IQR) | 0.5 (0.1–1.0) | 0.5 (0.2–0.6) | 0.687 |
Lung function tests | |||
VC (L), median (IQR) | 3.1 (2.5–4.0) | 2.8 (2.5–4.0) | 0.067 |
%VC (%), mean (SD) | 107.4 (16.1) | 94.5 (18.9) | 0.016 |
FVC (L), median (IQR) | 3.0 (2.5–3.9) | 2.5 (1.9–3.6) | 0.067 |
%FVC (%), mean (SD) | 98.8 (15.6) | 87.4 (18.7) | 0.027 |
FEV1 (L), median (IQR) | 2.3 (1.8–2.9) | 1.7 (1.3–2.9) | 0.104 |
%FEV1 (%), mean (SD) | 89.6 (19.1) | 80.1 (26.1) | 0.135 |
FEV1/FVC (%), median (IQR) | 75.2 (68.4–81) | 73.6 (64.3–83.4) | 0.958 |