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Fig. 5 | Respiratory Research

Fig. 5

From: Dual effects of human neutrophil peptides in a mouse model of pneumonia and ventilator-induced lung injury

Fig. 5

Effects of MRS2578 in pneumonia followed by mechanical ventilation. Mice were intranasally instilled with P. aeruginosa (1× 106 CFU) or PBS and received MRS2578 or vehicle (DMSO) 15 min, 24 h and 48 h after pneumonia, and then subjected to mechanical ventilation with either low (LP) or high (HP) pressure for 2 h. Bacteria counts (a) and neutrophil counts (b) in bronchoalveolar lavage fluid (BALF) were determined. c Lung permeability was determined by albumin concentration in BALF. d Lung injury score. N = 7 per group in P. aeruginosa groups, N = 5 per group in PBS groups. * p < 0.05 vs. FVB at identical conditions analyzed by Holm-Sidak test; † p < 0.05 vs. LP at identical conditions analyzed by multiple t tests; ¶ p < 0.05 vs. PBS at the identical conditions analyzed by multiple t tests; # p < 0.05 vs. DMSO at identical conditions analyzed by Tukey’s test, respectively

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