Clinical significance of radiological pleuroparenchymal fibroelastosis pattern in interstitial lung disease patients registered for lung transplantation: a retrospective cohort study

Table 3 Multivariable Cox proportional hazards model for mortality (n = 118)

	Transplant-censored			Competing analysis
Model 1	Hazard ratio	95%CI	p value	Hazard ratio	95%CI	P value
Radiological PPFE	0.51	(0.25, 1.05)	0.07	0.57	(0.30, 1.12)	0.10
Age	1.04	(1.01, 1.07)	0.01	1.03	(1.01, 1.06)	0.02
Male	1.05	(0.61, 1.82)	0.86	0.88	(0.51, 1.52)	0.65
%FVC	0.97	(0.95, 1.00)	0.03	0.98	(0.96, 1.00)	0.07
Six-minute walk distance < 250 m	1.87	(1.02, 3.43)	0.04	2.36	(1.33, 4.19)	0.003
Model 2
Category
Fibrotic ILDs^a without radiological PPFE	Ref.	–	–	Ref.	–	–
Idiopathic PPFE and LONIPC with radiological PPFE	0.38	(0.16, 0.90)	0.03	0.41	(0.21, 0.80)	0.01
Other fibrotic ILDs with radiological PPFE	0.96	(0.35, 2.64)	0.94	1.19	(0.51, 2.78)	0.69
Age	1.03	(1.00, 1.07)	0.02	1.03	(1.00, 1.06)	0.04
Male	1.01	(0.58, 1.75)	0.98	0.85	(0.49, 1.47)	0.56
%FVC	0.98	(0.95, 1.00)	0.03	0.98	(0.97, 1.00)	0.06
Six-minute walk distance < 250 m	1.99	(1.07, 3.70)	0.03	2.51	(1.39, 4.54)	0.002
Model 3
Category
Fibrotic ILDs without radiological PPFE	Ref.	–	–	Ref.	–	–
Idiopathic PPFE	0.35	(0.12, 1.04)	0.06	0.39	(0.20, 0.78)	0.01
LONIPC with radiological PPFE	0.42	(0.12, 1.50)	0.18	0.43	(0.35, 2.64)	0.15
Other fibrotic ILDs^a with radiological PPFE	0.96	(0.35, 2.64)	0.94	1.19	(0.51, 2.78)	0.69
Age	1.04	(1.00, 1.07)	0.02	1.03	(1.00, 1.07)	0.04
Male	1.01	(0.58, 1.75)	0.98	0.85	(0.58, 1.75)	0.57
%FVC	0.98	(0.95, 1.00)	0.03	0.98	(0.95, 1.00)	0.06
Six-minute walk distance < 250 m	2.00	(1.07, 3.74)	0.03	2.52	(1.39, 4.54)	0.003

^aOther fibrotic ILDs are IPF, other IIPs, CTD-ILD, and HP
Abbreviations: ILD interstitial lung disease, PPFE plueroparenchymal fibroelastosis, LONIPC late-onset non-infectious pulmonary complication after hematopoetic stem-cell transplantation and/or chemotherapy, %FVC the percentage to predicted forced vital capacity, IPF idiopathic pulmonary fibrosis, other IIPs other idiopathic interstitial pneumonias than idiopathic pulmonary fibrosis, CTD-ILD connective tissue disease-associated interstitial lung disease, HP hypersensitivity pneumonia

ISSN: 1465-993X