Table 2 Top 25 up-regulated genes in IPF vs. NSIP (SAM analysis)
NCBI Gene Symbol | NCBI Gene name | d | Fold change vs. NSIP group | q value |
|---|---|---|---|---|
IGFBP5 | insulin like growth factor binding protein 5 | 4.70 | 1.78 | < 0.0001 |
SLN | sarcolipin | 4.69 | 2.57 | < 0.0001 |
SYNPO2 | synaptopodin 2 | 4.61 | 2.08 | < 0.0001 |
MYH11 | myosin, heavy chain 11, smooth muscle | 4.38 | 1.99 | < 0.0001 |
DES | desmin | 4.33 | 2.05 | < 0.0001 |
NLGN4Y | neuroligin 4, Y-linked | 4.24 | 2.55 | < 0.0001 |
FAM83D | family with sequence similarity 83, member D | 4.23 | 1.65 | < 0.0001 |
ACTG2 | actin, gamma 2, smooth muscle, enteric | 4.16 | 2.25 | < 0.0001 |
TPM2 | tropomyosin 2 (beta) | 4.13 | 1.62 | < 0.0001 |
CNN1 | calponin 1, basic, smooth muscle | 4.06 | 1.77 | < 0.0001 |
PRUNE2 | prune homolog 2 (Drosophila) | 4.01 | 1.84 | < 0.0001 |
EIF1AY | eukaryotic translation initiation factor 1A, Y-linked | 4.00 | 7.99 | < 0.0001 |
RPS4Y1 | ribosomal protein S4, Y-linked 1 | 4.00 | 7.25 | < 0.0001 |
AHNAK2 | AHNAK nucleoprotein 2 | 3.93 | 1.76 | < 0.0001 |
DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | 3.91 | 11.4 | < 0.0001 |
KDM5D | lysine (K)-specific demethylase 5D | 3.89 | 5.23 | < 0.0001 |
TXLNGY | taxilin gamma pseudogene, Y-linked | 3.89 | 7.08 | < 0.0001 |
ATP1A2 | ATPase, Na+/K+ transporting, alpha 2 polypeptide | 3.87 | 1.66 | < 0.0001 |
ACTA-2 | actin, alpha 2, smooth muscle, aorta | 3.87 | 1.51 | < 0.0001 |
TXLNGY | taxilin gamma pseudogene, Y-linked | 3.86 | 5.71 | < 0.0001 |
ZFY | zinc finger protein, Y-linked | 3.79 | 4.13 | < 0.0001 |
PDLIM3 | PDZ and LIM domain 3 | 3.79 | 1.55 | < 0.0001 |
TAGLN | transgelin | 3.77 | 1.60 | < 0.0001 |
UTY | ubiquitously transcribed tetratricopeptide repeat | 3.72 | 7.80 | < 0.0001 |
IGFBP6 | insulin like growth factor binding protein 6 | 3.66 | 1.60 | < 0.0001 |