Comprehensive gene expression profiling identifies distinct and overlapping transcriptional profiles in non-specific interstitial pneumonia and idiopathic pulmonary fibrosis

Table 1 Demographic, clinical and functional characteristics of the patients included in the study

Variable	IPF (n = 22)	NSIP (n = 10)	p value
Male/Female (% males)	17/5 (77%)	2/8 (20%)	0.0051
Age (years)	62 ± 6	45 ± 11	< 0.0001
BMI (m/Kg²)	26 ± 5	24 ± 3	n.s.
mPAP (mmHg)⁺	29 ± 12	35 ± 21	n.s.
6MWD (m)	293 ± 103	292 ± 195	n.s.
FVC (% pred)	57 ± 19	49 ± 18	n.s.
TLC (% pred)	65 ± 14	65 ± 18	n.s.
DLCO (% pred)	37 ± 10	51 ± 18	0.0242
Treatment (% of total):
Prednisone alone	7 (31.8%)	5 (50%)	n.s.
Prednisone + Azathioprine	8 (36.4%)	2 (20%)	n.s.
NAC alone	1 (4.5%)	0 (0%)	n.s.
No specific treatment	6 (27.3%)	3 (30%)	n.s.

⁺intraoperative mPAP during lung transplant
IPF idiopathic pulmonary fibrosis, NSIP non-specific interstitial pneumonia, BMI body mass index, mPAP mean pulmonary arterial pressurem, 6MWD 6-min walk distance, FVC forced vital capacity, TLC total lung capacity, DLCO diffusing lung capacity for carbon monoxide, n.s. not significant

ISSN: 1465-993X