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Fig. 6 | Respiratory Research

Fig. 6

From: Regulatory role of heme oxygenase-1 in silica-induced lung injury

Fig. 6

Effect of HO-1 inducer/inhibitor on silica-induced ERK activation in RAW264.7 and 16HBE cells. Immunoblotting analysis showed that HO-1 inducer/inhibitor modulated silica-induced ERK activation in (a) RAW264.7 cells and (b) 16HBE cells. Cells were pretreated with hemin (HO-1 inducer) or ZnPP (HO-1 inhibitor) 1 h before silica exposure at the indicated concentrations and incubated as described in Fig. 4. Representative immunoblot images from three independent experiments are shown. Densitometric analysis of band intensity representing the mean ± SD level of pERK to ERK or HO-1 to actin from three independent experiments. # P < 0.05; ## P < 0.01 vs silica only

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