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Table 1 Baseline characteristics of P. aeruginosa VAP patients classified by LRT microbial similarity

From: Lower respiratory tract microbial composition was diversified in Pseudomonas aeruginosa ventilator-associated pneumonia patients

Characteristics

Pro cluster (n = 27)

Fir-Bac cluster (n = 9)

P value

Demographics

 Age, y

67.74 ± 14.55

69.78 ± 12.44

0.709

 Gender, female, n (%)

9 (33%)

6 (67%)

0.122

 BMI, kg/m2

23.45 ± 4.31

21.00 ± 4.40

0.152

 Smoker, n (%)

6(22%)

0 (0%)

0.303

Primary disease

 Respiratory diseasea, n (%)

2(7%)

8 (89%)

< 0.0001

 Gastrointestinal diseaseb, n (%)

17 (63%)

1 (11%)

 Neurological disease, n (%)

4 (15%)

0 (0%)

 Trauma, n (%)

2 (7%)

0 (0%)

 Bone and joint damage, n (%)

1 (4%)

0 (0%)

 Autoimmune disease, n (%)

1 (4%)

0 (0%)

Chronic coexisting disease

 Chronic bronchitis

3(11%)

1(11%)

1.000

 Chronic obstructive pulmonary disease

2 (7%)

0(0%)

1.000

 Diabetes, n (%)

3 (11%)

3 (33%)

0.151

 Hypertension, n (%)

12 (44%)

4 (44%)

1.000

Disease severity

 APACHE IIc

18 [16,24]

16 [9.5–24]

0.233

 SOFAc

8[2.5,10]

5[3,7]

0.263

Diagnosis of sepsis prior to sampling, n (%)

15 (55%)

6 (67%)

0.705

Time of P. aeruginosa VAP onset, dayd

15 [7–24]

14 [2–60.5]

0.971

  1. Abbreviations: VAP ventilator-associated pneumonia, BMI body mass index, APACHE II Acute Physiology and Chronic Health Evaluation II, SOFA Sequential Organ Failure Assessment
  2. a. 7 patients with severe pneumonia (not induced by P. aeruginosa), and 1 patient with pharyngeal abscess in Fir-Bac cluster and one with acute exacerbation of chronic obstructive pulmonary disease, and one with hypopharyngeal carcinoma in Pro cluster
  3. b. One patient with acute obstructive suppurative cholangitis in Fir-Bac cluster and 4 with gastrointestinal tumors, 6 with acute pancreatitis, 1 with bile duct stones, 1 with bile duct obstruction, 3 with intestinal obstruction and 2 with gastrointestinal perforation in Pro cluster
  4. c. APACHE II and SOFA scores were calculated within the first 24 h of ICU admission
  5. d. Time of P. aeruginosa VAP onset was defined as the interval from endotracheal intubation to diagnosis of P. aeruginosa VAP