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Table 1 Baseline characteristics of P. aeruginosa VAP patients classified by LRT microbial similarity

From: Lower respiratory tract microbial composition was diversified in Pseudomonas aeruginosa ventilator-associated pneumonia patients

Characteristics Pro cluster (n = 27) Fir-Bac cluster (n = 9) P value
Demographics
 Age, y 67.74 ± 14.55 69.78 ± 12.44 0.709
 Gender, female, n (%) 9 (33%) 6 (67%) 0.122
 BMI, kg/m2 23.45 ± 4.31 21.00 ± 4.40 0.152
 Smoker, n (%) 6(22%) 0 (0%) 0.303
Primary disease
 Respiratory diseasea, n (%) 2(7%) 8 (89%) < 0.0001
 Gastrointestinal diseaseb, n (%) 17 (63%) 1 (11%)
 Neurological disease, n (%) 4 (15%) 0 (0%)
 Trauma, n (%) 2 (7%) 0 (0%)
 Bone and joint damage, n (%) 1 (4%) 0 (0%)
 Autoimmune disease, n (%) 1 (4%) 0 (0%)
Chronic coexisting disease
 Chronic bronchitis 3(11%) 1(11%) 1.000
 Chronic obstructive pulmonary disease 2 (7%) 0(0%) 1.000
 Diabetes, n (%) 3 (11%) 3 (33%) 0.151
 Hypertension, n (%) 12 (44%) 4 (44%) 1.000
Disease severity
 APACHE IIc 18 [16,24] 16 [9.5–24] 0.233
 SOFAc 8[2.5,10] 5[3,7] 0.263
Diagnosis of sepsis prior to sampling, n (%) 15 (55%) 6 (67%) 0.705
Time of P. aeruginosa VAP onset, dayd 15 [7–24] 14 [2–60.5] 0.971
  1. Abbreviations: VAP ventilator-associated pneumonia, BMI body mass index, APACHE II Acute Physiology and Chronic Health Evaluation II, SOFA Sequential Organ Failure Assessment
  2. a. 7 patients with severe pneumonia (not induced by P. aeruginosa), and 1 patient with pharyngeal abscess in Fir-Bac cluster and one with acute exacerbation of chronic obstructive pulmonary disease, and one with hypopharyngeal carcinoma in Pro cluster
  3. b. One patient with acute obstructive suppurative cholangitis in Fir-Bac cluster and 4 with gastrointestinal tumors, 6 with acute pancreatitis, 1 with bile duct stones, 1 with bile duct obstruction, 3 with intestinal obstruction and 2 with gastrointestinal perforation in Pro cluster
  4. c. APACHE II and SOFA scores were calculated within the first 24 h of ICU admission
  5. d. Time of P. aeruginosa VAP onset was defined as the interval from endotracheal intubation to diagnosis of P. aeruginosa VAP