From: Health status decline in α-1 antitrypsin deficiency: a feasible outcome for disease modifying therapies?
Parameter
No. needed per arm to detect 25% reduction in decline
SGRQ total score
Whole group
8577
Rapid FEV1 decliners
5039
FEV1 (% predicted)
1516
86
Kco (% predicted)
569
Rapid Kco decliners
77