Table 1 Patient characteristics
No Obstruction | Obstruction | p | |||||
|---|---|---|---|---|---|---|---|
N | Median | IQR | N | Median | IQR | ||
Male n(%) | 33 (39%) | 235 (64%) | < 0.001 | ||||
Age | 84 | 42.4 | 35.5–53.9 | 370 | 52.5 | 46.4–58.5 | < 0.001 |
Index n(%) | 39 (46%) | 331 (89%) | < 0.001 | ||||
Never Smoker n(%) | 59 (70%) | 72 (19%) | < 0.001 | ||||
Pack Year History | 25 | 6.0 | 2.0–12.8 | 296 | 19.0 | 10.0–28.0 | < 0.001 |
BMI | 84 | 25.9 | 23.1–29.9 | 370 | 25.1 | 22.8–27.9 | 0.043 |
Baseline | |||||||
FEV1% predicted | 84 | 113.8 | 97.9–123.0 | 370 | 49.2 | 36.5–66.1 | < 0.001 |
FVC % predicted | 84 | 115.0 | 102.2–129.0 | 370 | 108.3 | 94.8–124.3 | 0.025 |
FEV1 / FVC Ratio | 84 | 80.6 | 77.2–86.0 | 370 | 37.6 | 30.3–48.0 | < 0.001 |
Tlco % predicted | 84 | 92.5 | 80.8–108.9 | 368 | 66.2 | 52.5–77.1 | < 0.001 |
Kco % predicted | 84 | 91.1 | 79.3–100.3 | 368 | 63.6 | 52.1–74.3 | < 0.001 |
SGRQ Symptoms | 84 | 30.9 | 11.7–57.1 | 370 | 62.5 | 46.2–78.6 | < 0.001 |
SGRQ Activity | 84 | 12.2 | 0–41.6 | 370 | 60.4 | 47.4–79.7 | < 0.001 |
SGRQ Impacts | 84 | 5.8 | 0–21.4 | 370 | 34.9 | 21.3–49.9 | < 0.001 |
SGRQ Total | 84 | 14.0 | 4.8–35.5 | 370 | 48.2 | 33.9–62.4 | < 0.001 |
Annual Decline | |||||||
FEV1% predicted Slope/yr | 84 | −0.25 | −1.11 – 0.47 | 370 | −1.02 | −1.99 – − 0.03 | < 0.001 |
Kco % predicted Slope/yr | 84 | −0.92 | −1.66 – 0.01 | 364 | −1.13 | −1.94 – −0.42 | 0.063 |
SGRQ Symptoms Slope/yr | 84 | 0.00 | −2.45 – 2.02 | 370 | 0.21 | −2.29 – 2.15 | 0.291 |
SGRQ Activity Slope/yr | 84 | 0.00 | −0.78 – 1.37 | 370 | 1.18 | −0.47 – 3.62 | < 0.001 |
SGRQ Impacts Slope/yr | 84 | 0.14 | −0.53 – 0.94 | 370 | 0.38 | −1.07 – 2.18 | 0.092 |
SGRQ Total Slope/yr | 84 | 0.21 | −0.76 – 1.06 | 370 | 0.66 | −0.83 – 2.37 | 0.025 |