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Table 5 Main results for meta-analysis between Ki-67 and clinicopathological features in lung cancer

From: Augmented expression of Ki-67 is correlated with clinicopathological characteristics and prognosis for lung cancer patients: an up-dated systematic review and meta-analysis with 108 studies and 14,732 patients

Clinicopathological features Study(n) Pooled OR(95%CIs) z P Heterogeneity Publication bias
I2 P Estimated method P
Age 19 1.246(1.039–1.494) 2.37 0.018 0.00% 0.967 Fixed-effect 0.234
Gender 26 1.874(1.385–2.535) 4.07 < 0.001 69.70% 0.000 Random-effect 1.000
Histological type 16 0.397(0.236–0.667) 3.49 < 0.001 81.20% 0.000 Random-effect 0.324
Differentiation 11 1.993(1.262–3.146) 2.96 0.003 66.30% 0.001 Random-effect 0.893
Pathologic stage 13 1.867(1.498–2.327) 5.56 < 0.001 23.10% 0.210 Fixed-effect 1.000
Tumor size 12 1.436(1.127–1.29) 2.93 0.003 0.00% 0.876 Fixed-effect 0.276
Tumor stage 11 1.287(0.882–1.877) 1.31 0.191 55.30% 0.013 Random-effect 0.086
Metastasis 4 2.609(0.667–10.204) 1.38 0.168 64.50% 0.038 Random-effect 0.428
Lymph node 23 1.653(1.285–2.127) 3.91 < 0.001 46.70% 0.008 Random-effect 0.876
TNM stage 8 1.497(1.053–2.126) 2.25 0.024 36.90% 0.134 Fixed-effect 0.187
Invasion 3 0.993(0.511–1.930) 0.02 0.984 14.20% 0.312 Fixed-effect 0.308
Smoking 15 3.087(2.504–3.8060) 10.56 < 0.001 39.40% 0.064 Fixed-effect 0.711