Augmented expression of Ki-67 is correlated with clinicopathological characteristics and prognosis for lung cancer patients: an up-dated systematic review and meta-analysis with 108 studies and 14,732 patients

Table 4 Meta-regression for the OS and DFS analysis

Variables	HR	Standard Error	t	P > \|t\|	Lower limit	Upper limit
OS
Year	0.999	0.104	−0.010	0.991	0.811	1.230
Region	0.835	0.061	−2.450	0.017	0.722	0.967
Cancer type	0.954	0.045	−0.990	0.326	0.868	1.049
Sample size	1.108	0.122	0.930	0.353	0.890	1.380
Cutoff value	0.777	0.084	−2.330	0.022	0.626	0.964
Statistical method	1.045	0.044	1.050	0.295	0.961	1.137
DFS
Year	2.011	1.525	0.920	0.377	0.379	10.678
Region	0.591	0.289	−1.070	0.306	0.201	1.736
Cancer type	1.125	0.401	0.330	0.747	0.513	2.467
Sample size	0.793	0.348	−0.530	0.607	0.302	2.081
Cutoff value	0.767	0.363	−0.560	0.587	0.271	2.172
Statistical method	0.994	0.221	−0.030	0.979	0.609	1.622

ISSN: 1465-993X