From: Serial blood eosinophils and clinical outcome in patients with chronic obstructive pulmonary disease
 | Persistently < 300 | Variable | Persistently ≥300 | P-value |
---|---|---|---|---|
Number | 175 | 68 | 56 | Â |
Age, years | 67.1 (7.6) | 66.0 (6.8) | 66.6 (7.3) | 0.59 |
Sex | Â | Â | Â | 0.18 |
 Female | 3 (1.7) | 4 (5.9) | 1 (1.8) |  |
 Male | 172 (98.3) | 64 (94.1) | 55 (98.2) |  |
Smoking history | Â | Â | Â | 0.28 |
 Current | 52 (29.7) | 23 (33.8) | 23 (41.1) |  |
 Ex-smoker | 123 (70.3) | 45 (66.2) | 33 (58.9) |  |
BMI, kg/m2 | 22.8 (3.5) | 23.5 (2.7) | 23.9 (3.0) | 0.07 |
Education | Â | Â | Â | 0.63 |
  < high school | 86 (49.1) | 30 (44.1) | 24 (42.9) |  |
  ≥ high school | 89 (50.9) | 38 (55.9) | 32 (57.1) |  |
mMRC ≥2 | 98 (56.0) | 31 (45.6) | 28 (50.0) | 0.32 |
SGRQ | ||||
 Symptoms | 44.1 (19.0) | 41.1 (18.8) | 46.3 (16.9) | 0.39 |
 Activity | 48.6 (22.9) | 46.0 (24.0) | 49.0 (22.3) | 0.68 |
 Impacts | 22.9 (18.2) | 18.2 (15.9) | 24.1 (18.8) | 0.17 |
 Total | 33.7 (17.5) | 30.7 (16.6) | 35.4 (17.5) | 0.29 |
Acute exacerbation in the previous yeara | ||||
  ≥ 2 Moderate AE | 15 (8.6) | 1 (1.5) | 6 (10.7) | 0.09 |
  ≥ 1 Severe AE | 19 (10.9) | 6 (8.8) | 7 (12.5) | 0.80 |
  ≥ 2 Moderate or ≥ 1 severe AE | 30 (17.1) | 7 (10.3) | 12 (21.4) | 0.23 |
Self-reported history of asthma | 52 (29.7) | 17 (25.0) | 15 (26.8) | 0.74 |
Spirometry | ||||
 FEV1 (mL) | 1398.7 (510.2) | 1538.1 (531.0) | 1533.9 (503.1) | 0.08 |
 FEV1, % predicted | 46.5 (15.7) | 50.7 (14.8) | 49.8 (14.2) | 0.10 |
 FVC (mL) | 3234.1 (784.1) | 3314.3 (800.4) | 3240.2 (775.5) | 0.77 |
 FVC, % predicted | 77.7 (17.6) | 79.9 (16.1) | 75.8 (15.3) | 0.41 |
 FEV1/FVC (%) | 43.1 (11.2) | 45.9 (9.3) | 47.3 (10.2) | 0.018 |
 Post-bronchodilator FEV1 (mL) | 1555.6 (531.7) | 1690.7 (537.9) | 1728.8 (554.1) | 0.052 |
 Post-bronchodilator FEV1, % predicted | 51.6 (16.1) | 55.9 (14.9) | 56.1 (15.4) | 0.06 |
 Post-bronchodilator FEV1 < 50%predicted, n(%) | 91 (52.0) | 42 (61.8) | 34 (60.7) | 0.28 |
 Positive reversibility, n (%) | 54 (30.9) | 21 (30.9) | 19 (33.9) | 0.91 |
Emphysema > 5%b | 137 (78.3) | 52 (76.5) | 43 (76.8) | 0.94 |
Inhaler use | ||||
 LAMA | 75 (42.9) | 22 (32.4) | 14 (25.0) | 0.036 |
 ICS/LABA or ICS | 71 (40.6) | 22 (32.4) | 28 (50.0) | 0.14 |
Blood Eosinophils | 143.4 (73.4) | 339.0 (191.6) | 681.0 (595.6) | < 0.001 |
Interval between two Eosinophil count, months | 12.2 (4.5) | 12.1 (4.0) | 12.9 (6.4) | 0.56 |