Fig. 4
From: Understanding alveolarization to induce lung regeneration
Approaches for lung regeneration. Identification of progenitors or stem cells and mediators driving cellular differentiation during alveolarization and neo-alveolarization might be used to identify possible target candidates to induce regeneration during pulmonary diseases such as emphysema/chronic obstructive lung dsease and fibrosis. Promising target candidates are represented by platelet-derived growth factor receptor (PDGFR)α+ cells and fibroblast growth factor (FGF)10 during alveolarization and bone morphogenic protein (BMP))/SMAD family member (SMAD) signaling and stromal cell derived factor (SDF)-1 during neo-alveolarization