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Fig. 8 | Respiratory Research

Fig. 8

From: PDGF-BB regulates the pulmonary vascular tone: impact of prostaglandins, calcium, MAPK- and PI3K/AKT/mTOR signalling and actin polymerisation in pulmonary veins of guinea pigs

Fig. 8

Relevance of relaxant signalling cascades in PDGFR-signalling in PVs. a Role of cAMP in PDGFR-signalling: (■) no pre-treatment / 100 nM PDGF-BB (n = 10); (grey square) 100 μM SQ22536 / 100 nM PDGF-BB (n = 10). b Role of NO in PDGFR-signalling: (■) no pre-treatment / 100 nM PDGF-BB (n = 10); (grey square) 100 μM L-NAME / 100 nM PDGF-BB (n = 10). c PDGF-BB increases intracellular cAMP: (□) no PDGF-BB (control) (n = 10); (■) 100 nM PDGF-BB (n = 11) a/b Statistics was performed by a LMM. C) Statistics was performed by the Mann-Whitney U test. P < 0.05 are considered as significant: * p < 0.05, ** p < 0.01 and *** p < 0.001

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