Skip to main content
Fig. 5 | Respiratory Research

Fig. 5

From: PDGF-BB regulates the pulmonary vascular tone: impact of prostaglandins, calcium, MAPK- and PI3K/AKT/mTOR signalling and actin polymerisation in pulmonary veins of guinea pigs

Fig. 5

PCLS: The role of prostaglandins in PDGF-BB-induced contraction in PVs. a Effect of inhibited cyclooxygenase on PDGF-BB-induced contraction: (■) no pre-treatment / 100 nM PDGF-BB (n = 8); (□) 3 μM indomethacin / 100 nM PDGF-BB (n = 8). b PDGF-BB-induced contraction is mediated via EP1/3-receptors: (■) no pre-treatment / 100 nM PDGF-BB (n = 8); (□) 1 μM SC51322 (EP1) / 100 nM PDGF-BB (n = 8); (grey square) 1 μM L798106 (EP3) / 100 nM PDGF-BB (n = 7). c PDGF-BB-induced contraction does not depend on EP2-receptors: (■) no pre-treatment / 100 nM PDGF-BB (n = 5); (□) 1 μM PF04418948 / 100 nM PDGF-BB (n = 5). d PDGF-BB-induced contraction depends on EP4-receptors: (■) no pre-treatment / 100 nM PDGF-BB (n = 5); (□) 1 μM L161982 / 100 nM PDGF-BB (n = 5). e PDGF-BB-induced contraction depends on TP-receptors: (■) no pre-treatment / 100 nM PDGF-BB (n = 7); (□) 10 μM SQ29548 / 100 nM PDGF-BB (n = 7). f PDGF-BB-induced contraction does not depend on IP-receptors: (■) no pre-treatment / 100 nM PDGF-BB (n = 4); (□) 1 μM RO-1138452 / 100 nM PDGF-BB (n = 4). a-f Statistics was performed by a LMM. P < 0.05 are considered as significant: * p < 0.05, ** p < 0.01 or *** p < 0.001

Back to article page

Respiratory Research

ISSN: 1465-993X

Contact us