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Fig. 3 | Respiratory Research

Fig. 3

From: PDGF-BB regulates the pulmonary vascular tone: impact of prostaglandins, calcium, MAPK- and PI3K/AKT/mTOR signalling and actin polymerisation in pulmonary veins of guinea pigs

Fig. 3

PCLS: PDGF-BB contracts PAs and PVs via activation of PDGFR-β. a PDGF-BB contracts PVs: (■) no pre-treatment / 100 nM PDGF-BB (n = 7); (grey square) 100 nM ponatinib / 100 nM PDGF-BB (n = 7); (□) 5 μM SU6668 / 100 nM PDGF-BB (n = 7). b The contractile effect of PDGF-BB in PAs: (●) no pre-treatment / 100 nM PDGF-BB (n = 7); (grey circle) 100 nM ponatinib / 100 nM PDGF-BB (n = 7); (○) 5 μM SU6668 / 100 nM PDGF-BB (n = 7). c PDGF-BB-induced contraction in PAs/PVs: (●) PAs: 100 nM PDGF-BB (n = 7); (■) PVs: 100 nM PDGF-BB (n = 7). a-c Statistics was performed by a LMM. P < 0.05 are considered as significant: * p < 0.05, ** p < 0.01 and *** p < 0.001

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Respiratory Research

ISSN: 1465-993X

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