Real world evaluation of a novel lateral flow assay (AlphaKit® QuickScreen) for the detection of alpha-1-antitrypsin deficiency

Table 4 Calculated predictive values in different clinical scenarios as reported in the literature

	Prevalence of Pi*Z positive carriers		NPV	PPV
European Population [4]	1:35	0.029	99.2	49.5
Primary Care in Spain [20]	1:31	0.032	99.1	52.0
Current Study	1:24	0.042	98.9	58.5
COPD II – IV in PFT [34]	1:22	0.046	98.7	61.2
Case finding in Germany [35]	1:30	0.303	89.6	93.4

PFT pulmonary function test, NPV negative predictive value, PPV positive predictive value

ISSN: 1465-993X