Microorganisms resistant to conventional antimicrobials in acute exacerbations of chronic obstructive pulmonary disease

Table 3 Clinical outcomes

	Patients with microorganisms resistant to conventional treatment (n = 34)	Patients with microorganisms sensitive to conventional treatment (n = 52)	Patients with negative microbiology (n = 109)	P value
AECOPD after 30 days of discharge, n (%)	24 (73)	21 (47)	57 (56)	0.070
Number of AECOPD after 30 days of discharge, median (IQR)	1 (0; 3)	0 (0; 2)	1 (0; 1)	0.075
Time to the next AECOPD, median (IQR), days	39 (19; 170)	52 (27; 166)	86 (26; 182)	0.577
Length of stay, median (IQR), days	9 (7; 14)^c	8 (6; 10.5)	8 (6; 10)^a	0.026
ICU admission, n (%)	4 (12)	6 (12)	12 (11)	0.981
IMV, n (%)	2 (6)	1 (2)	3 (2)	0.564
NIMV, n (%)	6 (18)	10 (19)	16 (15)	0.780
30-day mortality, n (%)	1 (3)	1 (2)	4 (4)	0.834
1-year mortality, n (%)	11 (32)	12 (23)	19 (17)	0.173
3-years mortality, n (%)	16 (59)	19 (56)	40 (43)	0.211

Abbreviations: AECOPD indicates acute exacerbation of chronic obstructive pulmonary disease exacerbation, ICU intensive care unit, IMV invasive mechanical ventilation, IQR interquartile range, NIMV non-invasive mechanical ventilation. Data are shown as number of patients (%), or median (1st quartile; 3rd quartile). Percentages are calculated on non-missing data. ^aP < 0.05 vs. patients with microorganisms resistant to conventional treatment. ^bp < 0.05 vs. patients with microorganisms sensitive to conventional treatment. ^cp < 0.05 vs. patients with negative microbiology

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