Fig. 5
From: Hsa_circ_0046264 up-regulated BRCA2 to suppress lung cancer through targeting hsa-miR-1245
Hsa_circ_0046264 overexpression inhibited tumor growth in vivo. a-b Tumor growth in hsa_circ_0046264 overexpression group (circ264) was slower than that in control group. Tumor volume and weight in circ264 group were smaller than that in control group. **P < 0.01, compared with control group. c The relative expression of hsa_circ_0046264 was higher in circ264 group than that in control group. *P < 0.05, compared with control group. d The relative expression of miR-1245 decreased while that of BRCA2 increased in tumor tissues of circ264 group. *P < 0.05, ***P < 0.001 compared with control group. e Immunohistochemistry result showed that the expression of BRCA2 protein increased in tumor tissues of circ264 group