Is IgE or eosinophils the key player in allergic asthma pathogenesis? Are we asking the right question?

Respiratory Research

Table 1 Direct effects of IgE on eosinophil functions

FcεRI-mediated	FcεRII-mediated
Activation and degranulation [32]	Expression of integrins (increased tissue migration) and prolonged survival [33]
Release of eosinophil peroxidase [34]	Release of TNF-α [35]

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