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Fig. 5 | Respiratory Research

Fig. 5

From: Hypoargininemia exacerbates airway hyperresponsiveness in a mouse model of asthma

Fig. 5

Similar changes in pulmonary content of inflammatory cytokines and OVA-specific IgE in asthmatic hypoargininemic and control mice. F/A2wt/wt (white bars) and F/A2tg/tg mice (black bars) were either mock-sensitized with PBS and challenged with ovalbumin (OVA; PBS/OVA), or sensitized and challenged with OVA (OVA/OVA) as indicated below the graphs. Cytokine or IgE concentrations were determined in lung tissue powder. Panel a-d: concentrations of IL4, IL13, IL10, and IgE, respectively, in plasma. The concentrations of IL13 and IL10 are expressed in arbitrary units. Means ± SEM of 7–8 mice per group. Significance symbols: *: P < 0.05 PBS/OVA vs. OVA/OVA F/A2wt/wt; #: P < 0.05 PBS/OVA vs. OVA/OVA F/A2tg/tg

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